Akcea Therapeutics (AKCA) versus Opko Health (OPK) Head-To-Head Comparison

Akcea Therapeutics (NASDAQ: AKCA) and Opko Health (NASDAQ:OPK) are both healthcare companies, but which is the better business? We will contrast the two companies based on the strength of their earnings, profitability, analyst recommendations, institutional ownership, dividends, valuation and risk.

Analyst Ratings

This is a summary of current ratings and recommmendations for Akcea Therapeutics and Opko Health, as provided by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Akcea Therapeutics 0 0 4 0 3.00
Opko Health 0 2 6 0 2.75

Akcea Therapeutics currently has a consensus price target of $24.00, indicating a potential upside of 27.80%. Opko Health has a consensus price target of $14.81, indicating a potential upside of 201.07%. Given Opko Health’s higher possible upside, analysts clearly believe Opko Health is more favorable than Akcea Therapeutics.


This table compares Akcea Therapeutics and Opko Health’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Akcea Therapeutics N/A N/A N/A
Opko Health -9.45% -5.17% -3.94%

Institutional and Insider Ownership

26.0% of Akcea Therapeutics shares are held by institutional investors. Comparatively, 22.9% of Opko Health shares are held by institutional investors. 40.2% of Opko Health shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

Earnings & Valuation

This table compares Akcea Therapeutics and Opko Health’s gross revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Akcea Therapeutics N/A N/A -$83.21 million ($3.94) -4.77
Opko Health $1.22 billion 2.25 -$25.08 million ($0.19) -25.89

Opko Health has higher revenue and earnings than Akcea Therapeutics. Opko Health is trading at a lower price-to-earnings ratio than Akcea Therapeutics, indicating that it is currently the more affordable of the two stocks.

About Akcea Therapeutics

Akcea Therapeutics, Inc. is a biopharmaceutical company. The Company is focused on developing and commercializing drugs to treat patients with serious cardiometabolic diseases caused by lipid disorders. The Company’s drugs, volanesorsen, AKCEA-APO(a)-LRx, AKCEA-ANGPTL3-LRx and AKCEA-APOCIII-LRx, are all based on antisense technology developed by Ionis Pharmaceuticals, Inc. (Ionis). The Company’s volanesorsen drug has completed a Phase III clinical program for the treatment of familial chylomicronemia syndrome (FCS) and is currently in Phase III clinical development for the treatment of familial partial lipodystrophy (FPL). The Company’s clinical pipeline contains drugs with the potential to treat inadequately addressed lipid disorders beyond elevated LDL-C that are contributing to the dramatic increase in the incidence of cardiometabolic disease, such as elevated triglycerides, oxidized phospholipids and other lipoproteins, such as lipoprotein(a), or Lp(a).

About Opko Health

OPKO Health, Inc. is a healthcare company. Its segments include Pharmaceutical, Diagnostics and Corporate. Pharmaceutical consists of the pharmaceutical operations in Chile, Mexico, Ireland, Israel and Spain and its pharmaceutical research and development operations. Diagnostics consists of the clinical laboratory operations in Bio-Reference Laboratories (Bio-Reference) and its point-of-care operations. Through Bio-Reference, it operates laboratory divisions, such as Bio-Reference, GenPath (Oncology), GenPath (Women’s Health), GeneDx and Laboratorio Bueno Salud. As of December 31, 2016, it had one commercial stage pharmaceutical product and several pharmaceutical compounds and technologies in various stages of research and development for a range of indications and conditions, including Renal Products, Biologics, hGH-CTP, Factor VII, Oxyntomodulin, active pharmaceutical ingredients, Oligonucleotide Therapeutics, NK-1 Program, Asthma and chronic obstructive pulmonary disease.

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