Critical Review: Tocagen (TOCA) & Its Competitors

Tocagen (NASDAQ: TOCA) is one of 289 public companies in the “Bio Therapeutic Drugs” industry, but how does it weigh in compared to its peers? We will compare Tocagen to related businesses based on the strength of its risk, institutional ownership, valuation, analyst recommendations, earnings, profitability and dividends.

Institutional and Insider Ownership

36.2% of Tocagen shares are owned by institutional investors. Comparatively, 49.6% of shares of all “Bio Therapeutic Drugs” companies are owned by institutional investors. 17.4% of shares of all “Bio Therapeutic Drugs” companies are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company is poised for long-term growth.

Earnings & Valuation

This table compares Tocagen and its peers gross revenue, earnings per share and valuation.

Gross Revenue Net Income Price/Earnings Ratio
Tocagen $40,000.00 -$33.47 million N/A
Tocagen Competitors $290.27 million $35.99 million 56.43

Tocagen’s peers have higher revenue and earnings than Tocagen.


This table compares Tocagen and its peers’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Tocagen -89,078.05% N/A -51.70%
Tocagen Competitors -5,443.85% -164.39% -36.43%

Analyst Ratings

This is a breakdown of current ratings and target prices for Tocagen and its peers, as provided by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Tocagen 0 0 2 0 3.00
Tocagen Competitors 1134 3423 11925 240 2.67

Tocagen currently has a consensus target price of $23.67, suggesting a potential upside of 95.27%. As a group, “Bio Therapeutic Drugs” companies have a potential upside of 39.57%. Given Tocagen’s stronger consensus rating and higher possible upside, research analysts plainly believe Tocagen is more favorable than its peers.


Tocagen peers beat Tocagen on 7 of the 11 factors compared.

Tocagen Company Profile

Tocagen Inc. (Tocagen) is a clinical-stage, cancer-selective gene therapy company. The Company is focused on developing product candidates designed to activate a patient’s immune system against their own cancer. Its cancer-selective gene therapy platform is built on retroviral replicating vectors (RRVs), which are designed to selectively deliver therapeutic genes into the deoxyribonucleic acid (DNA) of cancer cells. Its lead product candidates are vocimagene amiretrorepvec (Toca 511) and flucytosine extended release (Toca FC). Toca 511 is an investigational injectable retroviral replicating vector (RRV) that encodes a prodrug activator enzyme, cytosine deaminase (CD). Toca FC is an investigational extended-release version of 5-fluorocytosine (5-FC), a prodrug that is inactive as an anti-cancer drug. As of February, 2017, Tocagen has completed enrollment of the Phase II portion with 187 patients.

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